Could titin have a role in strain-induced injuries?

Could uric acid have a role in acute renal failure?

Acute renal failure (ARF), induced by either toxins or ischemia, is associated with significant morbidity. The pathogenesis of ARF is complex and is characterized by renal vasoconstriction and oxidative stress in association with tubular and microvascular injury and interstitial inflammation. In many situations, ARF is associated with a rise in serum uric acid as a result of both increased gene...

Could testosterone have a therapeutic role in prostate cancer?

PURPOSE To discuss the role of membrane androgen receptors and to investigate the potential role of testosterone-albumin conjugate in the prostate cancer (PCa) treatment. MATERIALS AND METHODS We identified studies published from 1990 onwards by searching the MEDLINE database of the National Library of Medicine. Initial search terms were "androgen receptors, cytoplasmic androgen receptor, and...

Could transient ischemic attacks have a cerebroprotective role?

1. Kaplan SS, Ogitvy CS, Gonzalez R, Gress D, Pile-Spellman J. Extracranial vertebral artery pseudoaneurysm presenting as subarachnoid hemorrhage. Stroke. 1993;24:1397-1399. 2. Saver JL, Easton JD, Hart RG. Dissections and trauma of cervicocerebral arteries. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM, eds. Stroke: Pathophysiology, Diagnosis, and Management. 2nd ed. New York, NY: Churchill Liv...

Reactive Oxygen Species and p38MAPK Have a Role in the Smad2 Linker Region Phosphorylation Induced by TGF-β

Background: Transforming growth factor-β (TGF-β) in addition to the C-terminal region can phosphorylate receptor-regulated Smads (R-Smads) in their linker region. The aim of the present study was to evaluate the role of signaling mediators such as NAD(P)H oxidases (reactive oxygen species [ROS] generators), ROS, and ROS-sensitive p38 mitogen-activated protein kinase (p38MAPK) in this signaling ...

Could Morality Have